Trisomic (Ts6rDn) Mouse Model of Down Syndrome
Overview
Dr. Elaine Bearer at Brown University and Dr. Russ Jacobs at Caltech recently published their findings in this transgenic mouse. Their studies compare active neuronal circuitry and anatomy in the hippocampal-septal memory circuit using a unique MR imaging technique of in vivo Mn2+ tract tracing. Data was collected from 15 mice and will be downloadable from here.
Contributors
Elaine Bearer, PhD
Russ Jacobs, PhD
References
Bearer, EL, Zhang, X and Jacobs, RE (2007). Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome. Neuroimage 37(1): 230-42.
Acknowledgement
This work was made possible through the following, Mouse BIRN Biomedical Informatics Research Network (Mouse BIRN) NIH/NCRR grant U24 RR021760, the Moore Foundation for the Moore Distinguished Scholar award that brought E.L.B. to Caltech to collaborate in this work, NINDS NS046810, NIGMS GM47368 (E.L.B.), and NIDA R01DA018184 (R.E.J.).