EPRIME Phase I


Description

These E-prime programs are the ones used during the FBIRN traveling subjects study of 2003 (the Phase I study; Series A, Step 3). These require the purchase and availability of E-prime from Psychology Software Tools, Inc. (http://www.pstnet.com/products/e-prime/) before they will run.

A full description of what each program does, its timing and measures is included in the downloadable protocols and instructions that were used to conduct the traveling subjects study (See User Manual below).

The paradigms include:

  1. a sensorimotor task;
  2. a breathhold task;
  3. a program for the resting scans;
  4. a Serial Item Recognition Paradigm (Sternberg, or SIRP);
  5. a “Mismatch Negativity” or MMN paradigm.

These were configured to run on displays that were 1280x1024, and to take input through the Serial Response Box (SRBox) from Psychology Software Tools. The fMRI compatible response box was wired to the SRBox.

All of these programs are provided as-is; they are not to be considered the best or only instantiation of these cognitive paradigms. They are the ones used in this experiment.

Installation information

To install any of these programs, download the chosen ZIP file to your preferred directory and unzip it. Each program needs to have its own directory. Double-click on the appropriate *.es file and compile it as you would any E-prime program.

Contributors/Authors

These programs were designed and implemented by these primary contributors:

  1. the sensorimotor task: Gary Glover and Lara Foland, Stanford University
  2. the breathhold task: Gary Glover and Lara Foland, Stanford University
  3. the program for the resting scans: Doug Greve, MGH; Lara Foland, Stanford University
  4. a Serial Item Recognition Paradigm (Sternberg, or SIRP): Dara Manoach, Doug Greve, Massachusetts General Hospital; Lara Foland, Stanford University
  5. a “Mismatch Negativity” or MMN paradigm: Cindy Wible, Brigham and Women’s Hospital; Doug Greve, Massachusetts General Hospital; Lara Foland, Stanford University

To download the EPRIME Phase I, please go to the download form.

Tutorial: Related tutorials can be found on the Function BIRN Tutorial Site.

References for the software
Relevant publications and conference presentations analyzing these data include (available at www.nbirn.net):

  1. Zou KH, Greve DN, Wang M, Pieper SD, Warfield SK, White NS, Vangel MG, Kikinis R, Wells WM, III, FIRST BIRN. (2004). A prospective multi-institutional study for the reproducibility of fMRI: a preliminary report from the Biomedical Informatics Research Network. Medical Image Computing and Computer-Assisted Intervention, St. Malot, France; published in Lecture Notes in Computer Science, 3217, 769-776. Springer: Berlin.
  2. Zou KH, Greve DN, Wang M, Pieper SD, Warfield SK, White NS, Manandhar S, Brown GG, Vangel MG, Kikinis R, Wells WM, III for the FIRST BIRN Research Group. (2005). Factors Impacting the Reproducibility of Functional MR Imaging: Preliminary Results of a Prospective Multi-Institutional Study by the Biomedical Informatics Research Network. Radiology, In press.
  3. Friedman, L., Glover, G.H., Krenz, D.E., Magnotta, V.A., FIRST BIRN. (2005). A Multi-center fMRI study of Scanner Variations in Sensitivity and Spatial Smoothness: Evidence for Field Strength and Vendor Effects. NeuroImage, In press.
  4. Lee, HJ, Turner, J., Potkin, SG., FIRST BIRN. (2005) Calibration Method of Functional Magnetic Resonance Images. Proceedings of the 2005 International Conference Imaging Science, Systems, and Technology: Computer Graphics (CISST'05), Las Vegas June 27-30 2005, pp 13-19.
  5. Kim, S. Smyth, P., Stern, H., Turner, J., FIRST BIRN. (2005) Parametric response surface models for analysis of multi-site fMRI data. Proceedings of the 8th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI). Lecture Notes in Computer Science, Springer-Verlag, Berlin Heidelberg New York, in press.
  6. 6. Potkin, S.G.; Turner, J.A.; Brown, G.G.; Glover, G.H.; Heckers, S.; Keator, D.B.; Grethe, J.S.; FIRST BIRN. (2003). Biomedical Informatics Research Network: Functional Imaging Research in Schizophrenia Testbed. Annual Meeting of the Sciety for Neuroscience, New Orleans, LA.
  7. Turner, J.A.; Potkin, S.G.; Brown, G.G.;Glover, G.H.; Greve, D.; Keator, D.B.; McCarthy, G.; Grethe, J.S.;Wible, C.G.; Lim, K.; Toga, A.W.; Andreasen, N.C.; O’Leary, D.; FIRST BIRN. (2003). Biomedical Informatics Research Network: Integrating multi-site human functional imaging acquisition and analysis. Biomedical Information Science and Technology Initiative (BISTI) Symposium, Bethesda, MD.
  8. Turner JA, Lee HJ, Wible C, McCarthy G, Potkin SG, FIRST BIRN. (2004). The stability of auditory activation in functional magnetic resonance imaging data across sessions and sites. Annual Meeting of the Cognitive Neuroscience Society, San Francisco, CA.
  9. Friedman, L., Posse, S., FIRST BIRN. (2004). Insights into Multi-Site FMRI Repeatability: Scanner Differences in Sensitivity and Smoothness. Annual Meeting of the Organization for Human Brain Mapping, Budapest, Hungary.
  10. Greve, D.N., White, N.S., Dale, A.M., FIRST-BIRN. (2004). Evaluation of fMRI Sensitivity Across Multiple Sites. Annual Meeting of the Organization for Human Brain Mapping, Budapest, Hungary.
  11. Turner, J.A., Potkin, S.G., Glover, G., McCarthy, G., Gollub, R.L., Brown, G., Dale, A., Grethe, J.S., Friedman, L., Keator, D.B., FIRST BIRN. (2004). Biomedical Informatics Research Network: Functional Imaging Research In Schizophrenia Testbed. Annual Meeting of the Organization for Human Brain Mapping, Budapest, Hungary.
  12. Zou, K.H., Greve, D.N., Wang, M., Pieper, S.D. Warfield, S.K., White, N.S., Vangel, M.G., Kikinis, R., Wells, W.M., FIRST BIRN. (2004). A Prospective Multi-Institutional Study of the Reproducibility of fMRI: A Preliminary Report from the Biomedical Informatics Research Network. Annual Meeting of the Organization for Human Brain Mapping, Budapest, Hungary.
  13. Friedman L, FIRST BIRN. (2004). An Index of Scanner/Site Differences in fMRI Sensitivity: Method and Implications. 12th Annual Meeting of the International Society for Magnetic Resonance Imaging (ISMRM), Kyoto, Japan.
  14. Friedman L, Magnotta VA, Posse S, FIRST BIRN. (2004). Scanner differences in the Smoothness of fMRI Images: Implications for Multi-Center Studies. 12th Annual Meeting of the International Society for Magnetic Resonance Imaging (ISMRM),Kyoto, Japan.
  15. Glover, G.H., Foland, L., FIRST BIRN. (2004). Scanner Quality Assurance for Longitudinal or Multicenter fMRI Studies. 12th Annual Meeting of the International Society for Magnetic Resonance Imaging (ISMRM), Kyoto, Japan.
  16. Glover, G.H., Thomason, M.E., Foland, L., FIRST BIRN. (2004). Calibration of fMRI Activation for the FIRST BIRN Project. 12th Annual Meeting of the International Society for Magnetic Resonance Imaging (ISMRM), Kyoto, Japan.
  17. Magnotta, V.A., Friedman, L., FIRST BIRN. (2004). SNR and CNR Measurements in the fBIRN Multicenter Study. 12th Annual Meeting of the International Society for Magnetic Resonance Imaging (ISMRM), Kyoto, Japan.
  18. Zou, K.H. Zou, Wang, M., Pieper, S.D., Kikinis, R. Kikinis, Wells, W.M. III, FIRST BIRN. (2004). Factors Impacting the Reproducibility of Functional MR Imaging: A Prospective Multi-Institutional Study by the Biomedical Informatics Research Network (BIRN). 12th Annual Meeting of the International Society for Magnetic Resonance Imaging (ISMRM), Kyoto, Japan.
  19. Zou KH, Pieper SD, Wang M, Warfield SK, Wells WM, III, Kikinis R, FIRST BIRN. (2004). An expectation-maximization algorithm for analyzing multi-center repeated functional magnetic resonance imaging (fMRI) data. Joint Statistical Meetings in Toronto, Ontario, Canada.
  20. Stern, H.S.; Kim, S-Y.; Smyth, P.J., FIRST BIRN. (2004). A variance components analysis of a multi-site fMRI study. Joint Statistical Meetings in Toronto, Ontario, Canada.
  21. Stern, H.S.; Kim, S-Y.; Smyth, P.J., van Dyk, D.; FIRST BIRN. (2004). A Variance Components Analysis of a Multi-Site fMRI Study. Annual Meeting of the International Society for Bayesian Analysis, Vina del Mar, Chile.
  22. Foland, L.C., Thomason, M.E., FIRST BIRN, Glover, G.H.. (2004). Calibrating Functional MRI Data Across Subjects And Scan Sites. Annual Meeting of the Society for Neuroscience, San Diego, California.
  23. Morris, S.K., Brown G.G., Glover G.H., Foland L.C, Bischoff-Grethe A., Liu T., Ozyurt B.I., Turner T., FIRST BIRN. (2004). The Stability Of Sensory Motor Activation In fMRI Across Sites: Initial Calibrations. Annual Meeting of the Society for Neuroscience, San Diego, California.
  24. Turner, J.A., Morris, S.K., Lee, H.J, Wible,C., Brown, G.G., Potkin, S.G., FIRST BIRN. (2004). The stability of auditory activation in fMRI across sessions and sites: Initial Calibrations. Annual Meeting of the Society for Neuroscience, San Diego, California.
  25. S.G. Potkin., G.G. Brown; G.H. Glover; G. McCarthy; K. O. Lim; R. Gollub; B. Rosen; A. Toga; R. Kikinis; A. Dale; J. Lauriello; D. O'Leary; J. Lieberman; A. Belger; D. Greve; L. Friedman; T. Cannon; D.B. Keator; J.S. Grethe; J.A. Turner; Function BIRN. (2004). Functional Biomedical Informatics Research Network: Multi-Center FMRI Methods. American College of Neuropsychopharmacology Meeting, San Juan, Puerto Rico.
  26. Potkin SG, Bunney WE, Dale A, Rosen B, Toga A, "Multiple Problems with Multi-Site Brain Imaging Studies", Abstract and poster presentation at the Winter Conference on Brain Research, Breckenridge, CO, January 2005.
  27. Turner, J., Potkin, S. G., Brown, G. G., Glover, G. H., Fallon, J. H., McCarthy, G., Lim, K. O., Gollub, R. L., Rosen, B. R., Toga, A. W., Kikinis, R., Pieper, S., Dale, A. M., Lauriello, J.. O'Leary, D. S., Lieberman, J. A., Belger, A., Greve, D. N., Friedman, L., Cannon, T. D., Keator, D. B., Grethe, J. S., Function BIRN. (2005) . Multi-Center fMRI Methods And Design: Function BIRN. International Congress of Schizophrenia Research, Savannah GA.
  28. Glover, Gary. (2005). Variability of Images Across Sites and Machines: the Biomedical Informatics Network (BIRN) Experience. NIfTI Neuroimaging Seminar, NIH, March 15, 2005.
  29. Friedman, L., Krenz, D., Magnotta, V., Functional BIRN (2005): Isolated Spike-Like Transients (ISLTs) in Functional MR Timeseries: Evidence for Vendor and Field Strength Effects on Rates. 13th Annual Meeting of the International Society for Magnetic Resonance Imaging (ISMRM), Miami Beach, FL.
  30. Friedman, L., Krenz, D.E., FIRST BIRN. (2005). Scanner and Field Strength Effects on the Shape of the Hemodynamic Response Function. Annual Meeting of the Organization for Human Brain Mapping, Toronto, Ontario, Canada, June 12-16th, 2005.
  31. Friedman, L., Krenz, D.E., FIRST BIRN. (2005). Field-Strength and Vendor Effects on the Degree of Temporal Autocorrelation in fMRI Timeseries. Annual Meeting of the Organization for Human Brain Mapping, Toronto, Ontario, Canada, June 12-16th, 2005.
  32. Friedman, L., Krenz, D.E., Magnotta, V.A., FIRST BIRN. (2005). Isolated Spike-like Transients (ISLTs) in Functional MR Timeseries: Evidence for Vendor and Field Strength Effects on Rates. Annual Meeting of the Organization for Human Brain Mapping, Toronto, Ontario, Canada, June 12-16th, 2005.

Technical Contacts

Jessica Turner

Acknowledgements and Funding Sources

NCRR (NIH), 5 MOI RR 000827